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Related  
Partner
Projects & Publications

Precision Medicine and Economics Projects and Publications from GEECS Members

Oncology Outcomes

Oncology Outcomes (O2), a highly experienced resource group dedicated to real-world evidence data generation and integration. Through this collaboration, Roche and O2 will work together to increase RWD acceptability and accessibility across the Canadian ecosystem.

Genesolve

​The GeneSolve Study examines the value of genomic sequencing for diagnosing childhood rare diseases. Through a cross-institutional collaboration with Oxford University, PACER is developing new ways to address the high levels of uncertainty introduced by multi-omics technologies. This multi-country approach to economic analyses will support the timely and appropriate adoption of genomics for better diagnosing and treating children with rare diseases across jurisdictions.

TRANSPERS Center

The Center for Translational and Policy Research on Precision Medicine (TRANSPERS) is the premier research organization for developing evidence-based information about the use of precision medicine.

PAVE

Producing an Arthritis Value-Framework with Economic Evidence (PAVE), will explore health-care system costs and impacts on families including financial, education, employment, productivity, well-being and quality of life

Related Publications

  • Lynch F, Meng Y, Best S, Goranitis I, Savulescu J, Gyngell C, Vears DF. Australian public perspectives on genomic data storage and sharing: Benefits, concerns and access preferences. Eur J Med Genet. 2022 Dec 5;66(1):104676. Epub ahead of print. PMID: 36473622.

  • Cuppen E, Elemento O, Rosenquist R, Nikic S, IJzerman M, Zaleski ID, Frederix G, Levin LÅ, Mullighan CG, Buettner R, Pugh TJ, Grimmond S, Caldas C, Andre F, Custers I, Campo E, van Snellenberg H, Schuh A, Nakagawa H, von Kalle C, Haferlach T, Fröhling S, Jobanputra V. Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care. JCO Precis Oncol. 2022 Dec;6:e2200245. PMID: 36480778.

  • Smith HS, Bonkowski ES, Deloge RB, Gutierrez AM, Recinos AM, Lavelle TA, Veenstra DL, McGuire AL, Pereira S. Key drivers of family-level utility of pediatric genomic sequencing: a qualitative analysis to support preference research. Eur J Hum Genet. 2022 Nov 25. Epub ahead of print. PMID: 36434257.

  • Regier DA, Chan B, Costa S, Scott DW, Steidl C, Connors JM, Karsan A, Marra MA, Kridel R, Cromwell I, Pollard S. Cost-Effectiveness of Molecularly Guided Treatment in Diffuse Large B-Cell Lymphoma (DLBCL) in Patients under 60. Cancers (Basel). 2022 Feb 12;14(4):908. PMID: 35205656; PMCID: PMC8870002.

  • Kang YJ, O'Haire S, Franchini F, IJzerman M, Zalcberg J, Macrae F, Canfell K, Steinberg J. A scoping review and meta-analysis on the prevalence of pan-tumour biomarkers (dMMR, MSI, high TMB) in different solid tumours. Sci Rep. 2022 Nov 28;12(1):20495. PMID: 36443366; PMCID: PMC9705554.

  • Briggs SEW, Law P, East JE, Wordsworth S, Dunlop M, Houlston R, Hippisley-Cox J, Tomlinson I. Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis using UK Biobank data: population based cohort study. BMJ. 2022 Nov 9;379:e071707. PMID: 36351667; PMCID: PMC9644277.

  • Jegathisawaran J, Tsiplova K, Hayeems RZ, Marshall CR, Stavropoulos DJ, Pereira SL, Thiruvahindrapuram B, Liston E, Reuter MS, Manshaei R, Cohn I, Jobling R, Kim RH, Mital S, Ungar WJ. Trio genome sequencing for developmental delay and pediatric heart conditions: A comparative microcost analysis. Genet Med. 2022 May;24(5):1027-1036. Epub 2022 Feb 24. PMID: 35219592.

  • Smith HS, Sanchez CE, Maag R, Buentello A, Murdock DR, Metcalf GA, Hadley TD, Riconda DL, Boerwinkle E, Wehrens XHT, Ballantyne CM, Gibbs RA, McGuire AL, Pereira S. Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study. Circ Genom Precis Med. 2022 Oct 25:e003605. doi: 10.1161/CIRCGEN.121.003605. Epub ahead of print. PMID: 36282588.

  • Regier DA, Pollard S, McPhail M, Bubela T, Hanna TP, Ho C, Lim HJ, Chan K, Peacock SJ, Weymann D. A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada. NPJ Precis Oncol. 2022 Oct 25;6(1):76. PMID: 36284134; PMCID: PMC9596463.

  • Hermansen A, Regier DA, Pollard S. Developing Data Sharing Models for Health Research with Real-World Data: A Scoping Review of Patient and Public Preferences. J Med Syst. 2022 Oct 22;46(12):86. PMID: 36271208.

  • Huygens S, Vellekoop H, Versteegh M, Santi I, Szilberhorn L, Zelei T, Nagy B, Tsiachristas A, Koleva-Kolarova R, Wordsworth S, Rutten-van Mölken M; HEcoPerMed Consortium. Cost-Effectiveness Analysis of Treating Patients With NTRK-Positive Cancer With the Histology-Independent Therapy Entrectinib. Value Health. 2022 Oct 10:S1098-3015(22)02146-5. Epub ahead of print. PMID: 36229359.

  • Hayeems RZ, Luca S, Hurst ACE, Cochran M, Owens C, Hossain A, Chad L, Meyn MS, Pullenayegum E, Ungar WJ, Bick D. Applying the Clinician-reported Genetic testing Utility InDEx (C-GUIDE) to genome sequencing: further evidence of validity. Eur J Hum Genet. 2022 Oct 4. Epub ahead of print. PMID: 36195708.

  • Hayeems RZ, Bernier F, Boycott KM, Hartley T, Michaels-Igbokwe C, Marshall DA. Positioning whole exome sequencing in the diagnostic pathway for rare disease to optimise utility: a protocol for an observational cohort study and an economic evaluation. BMJ Open. 2022 Oct 10;12(10):e061468. PMID: 36216418.

  • Buchanan J, Goranitis I, Slade I, Kerasidou A, Sheehan M, Sideri K, Wordsworth S. Resource allocation in genetic and genomic medicine. J Community Genet. 2022 Sep 24. Epub ahead of print. PMID: 36152236.

  • O'Haire S, Degeling K, Franchini F, Tran B, Luen SJ, Gaff C, Smith K, Fox S, Desai J, IJzerman M. Comparing Survival Outcomes for Advanced Cancer Patients Who Received Complex Genomic Profiling Using a Synthetic Control Arm. Target Oncol. 2022 Sep 5. Epub ahead of print. PMID: 36063280.

  • Wheeler JCW, Keogh L, Sierra MA, Devereux L, Jones K, IJzerman MJ, Trainer AH. Heterogeneity in how women value risk-stratified breast screening. Genet Med. 2022 Jan;24(1):146-156.  Epub 2021 Nov 30. PMID: 34906505.

  • Berrigan P, Hicks GG, Ungar WJ, Zwicker JD. Budget Impact Analysis of an Epigenetic Test Used for Diagnosing Fetal Alcohol Spectrum Disorder from the Perspective of a Laboratory Budget Holder in Manitoba, Canada. Pharmacoecon Open. 2022 Mar;6(2):253-263. Epub 2021 Oct 10. PMID: 34628597; PMCID: PMC8863997.

  • Enzing JJ, Knies S, Engel J, IJzerman MJ, Sander B, Vreman R, Boer B, Brouwer WBF. Do Health Technology Assessment organisations consider manufacturers' costs in relation to drug price? A study of reimbursement reports. Cost Eff Resour Alloc. 2022 Aug 31;20(1):46.  PMID: 36045377; PMCID: PMC9434877.

  • Glewis S, Alexander M, Lingaratnam S, Lee B, Campbell I, Krishnasamy M, IJzerman M, Fagery M, Harris S, Georgiou C, Underhill C, Warren M, Campbell R, Martin J, Tie J, Michael M. Pharmacogenomics guided dosing for fluoropyrimidine and irinotecan chemotherapies for patients with cancer (PACIFIC-PGx): study protocol of a multicentre clinical trial. Acta Oncol. 2022 Aug 16:1-4. Epub ahead of print. PMID: 35972781.

  • Pataky RE, Bryan S, Sadatsafavi M, Peacock S, Regier DA. Tools for the Economic Evaluation of Precision Medicine: A Scoping Review of Frameworks for Valuing Heterogeneity-Informed Decisions. Pharmacoeconomics. 2022 Jul 27.  Epub ahead of print. PMID: 35895254.

  • Arias JJ, Lin GA, Tyler AM, Douglas MP, Phillips KA. Geriatricians' Perspectives on the Multiple Dimensions of Utility of Genetic Testing for Alzheimer's Disease: A Qualitative Study. J Alzheimers Dis. 2022 Jul 20. Epub ahead of print. PMID: 35871355.

  • Rosenquist R, Cuppen E, Buettner R, Caldas C, Dreau H, Elemento O, Frederix G, Grimmond S, Haferlach T, Jobanputra V, Meggendorfer M, Mullighan CG, Wordsworth S, Schuh A. Clinical utility of whole-genome sequencing in precision oncology. Semin Cancer Biol. 2022 Sep;84:32-39. Epub 2021 Jun 25. PMID: 34175442.

  • Smith HS. Genomic Medicine's Critical Outcome Measure-Utility. JAMA Netw Open. 2022 Aug 1;5(8):e2225988. PMID: 35947388.

  • Ferket BS, Baldwin Z, Murali P, Pai A, Mittendorf KF, Russell HV, Chen F, Lynch FL, Lich KH, Hindorff LA, Savich R, Slavotinek A, Smith HS, Gelb BD, Veenstra DL. Cost-effectiveness frameworks for comparing genome and exome sequencing versus conventional diagnostic pathways: A scoping review and recommended methods. Genet Med. 2022 Jul 13:S1098-3600(22)00813-9.  Epub ahead of print. PMID: 35833928.

  • Meng Y, Clarke PM, Goranitis I. The Value of Genomic Testing: A Contingent Valuation Across Six Child- and Adult-Onset Genetic Conditions. Pharmacoeconomics. 2022 Feb;40(2):215-223. Epub 2021 Oct 21. PMID: 34671943.

  • Kunst N, Stout NK, O'Brien G, Christensen KD, McMahon PM, Wu AC, Diller LR, Yeh JM. Population-Based Newborn Screening for Germline TP53 Variants: Clinical Benefits, Cost-Effectiveness, and Value of Further Research. J Natl Cancer Inst. 2022 May 9;114(5):722-731. PMID: 35043946; PMCID: PMC9086756.

  • Wu Y, Balasubramaniam S, Rius R, Thorburn DR, Christodoulou J, Goranitis I. Genomic sequencing for the diagnosis of childhood mitochondrial disorders: a health economic evaluation. Eur J Hum Genet. 2022 May;30(5):577-586. Epub 2021 Jun 8. PMID: 34099885; PMCID: PMC9090793.

  • Padula WV, Kreif N, Vanness DJ, Adamson B, Rueda JD, Felizzi F, Jonsson P, IJzerman MJ, Butte A, Crown W. Machine Learning Methods in Health Economics and Outcomes Research-The PALISADE Checklist: A Good Practices Report of an ISPOR Task Force. Value Health. 2022 Jul;25(7):1063-1080. PMID: 35779937.

  • Buchanan J, Hill M, Vass CM, Hammond J, Riedijk S, Klapwijk JE, Harding E, Lou S, Vogel I, Hui L, Ingvoldstad-Malmgren C, Soller MJ, Ormond KE, Choolani M, Zheng Q, Chitty LS, Lewis C. Factors that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey. Prenat Diagn. 2022 Jun;42(7):934-946. PMID: 35476801.

  • Thomas M, Marshall DA, Choudhary D, Bartlett SJ, Sanchez AL, Hazlewood GS. The Application of Preference Elicitation Methods in Clinical Trial Design to Quantify Trade-Offs: A Scoping Review. Patient. 2022 Jul;15(4):423-434. PMID: 34927216.

  • McTaggart-Cowan H, King MT, Norman R, Costa DSJ, Pickard AS, Viney R, Peacock SJ, Regier D; Canadian MAUCa Team. The FACT-8D, a new cancer-specific utility algorithm based on the Functional Assessment of Cancer Therapies-General (FACT-G): a Canadian valuation study. Health Qual Life Outcomes. 2022 Jun 16;20(1):97. PMID: 35710417; PMCID: PMC9205108.

  • Armstrong B, Christensen KD, Genetti CA, Parad RB, Robinson JO, Blout Zawatsky CL, Zettler B, Beggs AH, Holm IA, Green RC, McGuire AL, Smith HS, Pereira S; BabySeq Project Team. Parental Attitudes Toward Standard Newborn Screening and Newborn Genomic Sequencing: Findings From the BabySeq Study. Front Genet. 2022 Apr 27;13:867371.  PMID: 35571041; PMCID: PMC9091188.

  • Tessier-Cloutier B, Grewal JK, Jones MR, Pleasance E, Shen Y, Cai E, Dunham C, Hoang L, Horst B, Huntsman DG, Ionescu D, Karnezis AN, Lee AF, Lee CH, Lee TH, Twa DD, Mungall AJ, Mungall K, Naso JR, Ng T, Schaeffer DF, Sheffield BS, Skinnider B, Smith T, Williamson L, Zhong E, Regier DA, Laskin J, Marra MA, Gilks CB, Jones SJ, Yip S. The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies. J Pathol Clin Res. 2022 Jul;8(4):395-407. Epub 2022 Mar 8. PMID: 35257510; PMCID: PMC9161328.

  • de Rouw N, de Boer M, Boosman RJ, van den Heuvel MM, Burger DM, Lieverse JE, Derijks HJ, Frederix GWJ, Ter Heine R. The Pharmacoeconomic Benefits of Pemetrexed Dose Individualization in Patients With Lung Cancer. Clin Pharmacol Ther. 2022 May;111(5):1103-1110. Epub 2022 Feb 21. PMID: 35048355.

  • Hayeems RZ, Marshall CR, Gillespie MK, Szuto A, Chisholm C, Stavropoulos DJ, Venkataramanan V, Tsiplova K, Sawyer S, Price EM, Lau L, Khan R, Lee W, Huang L, Jarinova O, Ungar WJ, Mendoza-Londono R, Somerville MJ, Boycott KM. Comparing genome sequencing technologies to improve rare disease diagnostics: a protocol for the evaluation of a pilot project, Genome-wide Sequencing Ontario. CMAJ Open. 2022 May 24;10(2):E460-E465. PMID: 35609929.

  • Kip MMA, de Roock S, Currie G, Marshall DA, Grazziotin LR, Twilt M, Yeung RSM, Benseler SM, Vastert SJ, Wulffraat N, Swart JF, IJzerman MJ. Pharmacological treatment patterns in patients with juvenile idiopathic arthritis in the Netherlands: a real-world data analysis. Rheumatology (Oxford). 2022 May 18:keac299.  Epub ahead of print. PMID: 35583252.

  • Koleva-Kolarova R, Buchanan J, Vellekoop H, Huygens S, Versteegh M, Mölken MR, Szilberhorn L, Zelei T, Nagy B, Wordsworth S, Tsiachristas A; HEcoPerMed Consortium. Financing and Reimbursement Models for Personalised Medicine: A Systematic Review to Identify Current Models and Future Options. Appl Health Econ Health Policy. 2022 Apr 4. Epub ahead of print. PMID: 35368231.

  • Marouane A, Olde Keizer RACM, Frederix GWJ, Vissers LELM, de Boode WP, van Zelst-Stams WAG. Congenital anomalies and genetic disorders in neonates and infants: a single-center observational cohort study. Eur J Pediatr. 2022 Jan;181(1):359-367. Epub 2021 Aug 4. PMID: 34347148; PMCID: PMC8760213.

  • Dixon P, Keeney E, Taylor JC, Wordsworth S, Martin RM. Can polygenic risk scores contribute to cost-effective cancer screening? A systematic review. Genet Med. 2022 May 16:S1098-3600(22)00749-3. Epub ahead of print. PMID: 35575786.

  • Smit AK, Allen M, Beswick B, Butow P, Dawkins H, Dobbinson SJ, Dunlop KL, Espinoza D, Fenton G, Kanetsky PA, Keogh L, Kimlin MG, Kirk J, Law MH, Lo S, Low C, Mann GJ, Reyes-Marcelino G, Morton RL, Newson AJ, Savard J, Trevena L, Wordsworth S, Cust AE. Impact of personal genomic risk information on melanoma prevention behaviors and psychological outcomes: a randomized controlled trial. Genet Med. 2021 Dec;23(12):2394-2403. Epub 2021 Aug 12. PMID: 34385669; PMCID: PMC8629758.

  • Smith HS, Morain SR, Robinson JO, Canfield I, Malek J, Rubanovich CK, Bloss CS, Ackerman SL, Biesecker B, Brothers KB, Goytia CN, Horowitz CR, Knight SJ, Koenig B, Kraft SA, Outram S, Rini C, Shipman KJ, Waltz M, Wilfond B, McGuire AL. Perceived Utility of Genomic Sequencing: Qualitative Analysis and Synthesis of a Conceptual Model to Inform Patient-Centered Instrument Development. Patient. 2022 May;15(3):317-328. Epub 2021 Oct 18. PMID: 34658003; PMCID: PMC9013723.

  • Thom H, Leahy J, Jansen JP. Network Meta-analysis on Disconnected Evidence Networks When Only Aggregate Data Are Available: Modified Methods to Include Disconnected Trials and Single-Arm Studies while Minimizing Bias. Med Decis Making. 2022 May 7:272989X221097081.  Epub ahead of print. PMID: 35531938.

  • Kunst N, Stout NK, O'Brien G, Christensen KD, McMahon PM, Wu AC, Diller LR, Yeh JM. Population-Based Newborn Screening for Germline TP53 Variants: Clinical Benefits, Cost-Effectiveness, and Value of Further Research. J Natl Cancer Inst. 2022 May 9;114(5):722-731. PMID: 35043946; PMCID: PMC9086756.

  • Leppig KA, Kulchak Rahm A, Appelbaum P, Aufox S, Bland ST, Buchanan A, Christensen KD, Chung WK, Clayton EW, Crosslin D, Denny J, DeVange S, Gordon A, Green RC, Hakonarson H, Harr MH, Henrikson N, Hoell C, Holm IA, Kullo IJ, Jarvik GP, Lammers PE, Larson EB, Lindor NM, Marasa M, Myers MF, Perez E, Peterson JF, Pratap S, Prows CA, Ralston JD, Rasouly HM, Roden DM, Sharp RR, Singh R, Shaibi G, Smith ME, Sturm A, Thiese HA, Van Driest SL, Williams J, Williams MS, Wynn J, Blout Zawatsky CL, Wiesner GL. The reckoning: The return of genomic results to 1444 participants across the eMERGE3 Network. Genet Med. 2022 May;24(5):1130-1138. Epub 2022 Feb 23. PMID: 35216901.

  • Degeling K, IJzerman MJ, Groothuis-Oudshoorn CGM, Franken MD, Koopman M, Clements MS, Koffijberg H. Comparing Modeling Approaches for Discrete Event Simulations With Competing Risks Based on Censored Individual Patient Data: A Simulation Study and Illustration in Colorectal Cancer. Value Health. 2022 Jan;25(1):104-115. Epub 2021 Sep 8. PMID: 35031089.

  • Tsiachristas A, Vallance G, Koleva-Kolarova R, Taylor H, Solomons L, Rizzo G, Chaytor C, Miah J, Wordsworth S, Hassan AB. Can upfront DPYD extended variant testing reduce toxicity and associated hospital costs of fluoropyrimidine chemotherapy? A propensity score matched analysis of 2022 UK patients. BMC Cancer. 2022 Apr 26;22(1):458. PMID: 35473510; PMCID: PMC9044697.

  • Vass C, Boeri M, Karim S, Marshall D, Craig B, Ho KA, Mott D, Ngorsuraches S, Badawy SM, Mühlbacher A, Gonzalez JM, Heidenreich S. Accounting for Preference Heterogeneity in Discrete-Choice Experiments: An ISPOR Special Interest Group Report. Value Health. 2022 May;25(5):685-694. PMID: 35500943.

  • Buchanan J, Hill M, Vass CM, Hammond J, Riedijk S, Klapwijk JE, Harding E, Lou S, Vogel I, Hui L, Ingvoldstad-Malmgren C, Soller MJ, Ormond KE, Choolani M, Zheng Q, Chitty LS, Lewis C. Factor's that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey. Prenat Diagn. 2022 Apr 27. Epub ahead of print. PMID: 35476801.

  • Shickh S, Oldfield LE, Clausen M, Mighton C, Sebastian A, Calvo A, Baxter NN, Dawson L, Penney LS, Foulkes W, Basik M, Sun S, Schrader KA, Regier DA, Karsan A, Pollett A, Pugh TJ, Kim RH, Bombard Y; CHARM Consortium. "Game Changer": Health Professionals' Views on the Clinical Utility of Circulating Tumor DNA Testing in Hereditary Cancer Syndrome Management. Oncologist. 2022 Apr 6:oyac039. Epub ahead of print. PMID: 35385106.

  • Xie X, Tiggelaar S, Guo J, Wang M, Vandersluis S, Ungar WJ. Developing Economic Models for Assessing the Cost-Effectiveness of Multiple Diagnostic Tests: Methods and Applications. Med Decis Making. 2022 Apr 3:272989X221089268. Epub ahead of print. PMID: 35373634.

  • Koleva-Kolarova R, Buchanan J, Vellekoop H, Huygens S, Versteegh M, Mölken MR, Szilberhorn L, Zelei T, Nagy B, Wordsworth S, Tsiachristas A; HEcoPerMed Consortium. Financing and Reimbursement Models for Personalised Medicine: A Systematic Review to Identify Current Models and Future Options. Appl Health Econ Health Policy. 2022 Apr 4. Epub ahead of print. PMID: 35368231.

  • Lavelle TA, Feng X, Keisler M, Cohen JT, Neumann PJ, Prichard D, Schroeder BE, Salyakina D, Espinal PS, Weidner SB, Maron JL. Cost-effectiveness of exome and genome sequencing for children with rare and undiagnosed conditions. Genet Med. 2022 Apr 8:S1098-3600(22)00682-7. Epub ahead of print. PMID: 35396982.

  • McPhail M, McCabe C, Regier DA, Bubela T. The Importance of and Challenges with Adopting Life-Cycle Regulation and Reimbursement in Canada. Healthc Policy. 2022 Feb;17(3):81-90. PMID: 35319446; PMCID: PMC8935925.

  • Pataky R, Tran DA, Coronado A, Alvi R, Boehm D, Regier DA, Peacock S. Cancer drug expenditure in British Columbia and Saskatchewan: a trend analysis. CMAJ Open. 2018 Jul 27;6(3):E292-E299. PMID: 30054297; PMCID: PMC6182106.

  • van de Ven M, IJzerman M, Retèl V, van Harten W, Koffijberg H. Developing a dynamic simulation model to support the nationwide implementation of whole genome sequencing in lung cancer. BMC Med Res Methodol. 2022 Mar 27;22(1):83. PMID: 35350994; PMCID: PMC8962015.

  • Weymann D, Pollard S, Chan B, Titmuss E, Bohm A, Laskin J, Jones SJM, Pleasance E, Nelson J, Fok A, Lim H, Karsan A, Renouf DJ, Schrader KA, Sun S, Yip S, Schaeffer DF, Marra MA, Regier DA. Clinical and cost outcomes following genomics-informed treatment for advanced cancers. Cancer Med. 2021 Aug;10(15):5131-5140. PMID: 34152087; PMCID: PMC8335838.

  • Deverka PA, Douglas MP, Phillips KA. Multicancer Screening Tests: Anticipating And Addressing Considerations For Payer Coverage And Patient Access. Health Aff (Millwood). 2022 Mar;41(3):383-389. PMID: 35254936.

  • Lin GA, Trosman JR, Douglas MP, Weldon CB, Scheuner MT, Kurian A, Phillips KA. Influence of payer coverage and out-of-pocket costs on ordering of NGS panel tests for hereditary cancer in diverse settings. J Genet Couns. 2022 Feb;31(1):130-139. PMID: 34231930; PMCID: PMC8893352.

  • Brunette CA, Dong OM, Vassy JL, Danowski ME, Alexander N, Antwi AA, Christensen KD. A Cost-Consequence Analysis of Preemptive SLCO1B1 Testing for Statin Myopathy Risk Compared to Usual Care. J Pers Med. 2021 Oct 31;11(11):1123. PMID: 34834475; PMCID: PMC8624003.

  • Morrell L, Buchanan J, Rees S, Barker RW, Wordsworth S. What Aspects of Illness Influence Public Preferences for Healthcare Priority Setting? A Discrete Choice Experiment in the UK. Pharmacoeconomics. 2021 Dec;39(12):1443-1454. Epub 2021 Aug 19. PMID: 34409564; PMCID: PMC8599241.

  • Vellekoop H, Versteegh M, Huygens S, Corro Ramos I, Szilberhorn L, Zelei T, Nagy B, Tsiachristas A, Koleva-Kolarova R, Wordsworth S, Rutten-van Mölken M; HEcoPerMed consortium. The Net Benefit of Personalized Medicine: A Systematic Literature Review and Regression Analysis. Value Health. 2022 Mar 2:S1098-3015(22)00056-0. Epub ahead of print. PMID: 35248467.

  • Halley MC, Smith HS, Ashley EA, Goldenberg AJ, Tabor HK. A call for an integrated approach to improve efficiency, equity and sustainability in rare disease research in the United States. Nat Genet. 2022 Mar;54(3):219-222. PMID: 35256804.

  • Jansen JP, Trikalinos TA, Phillips KA. Assessments of the Value of New Interventions Should Include Health Equity Impact. Pharmacoeconomics. 2022 Mar 3:1–7.  Epub ahead of print. PMID: 35237944; PMCID: PMC8890816.

  • Jegathisawaran J, Tsiplova K, Hayeems RZ, Marshall CR, Stavropoulos DJ, Pereira SL, Thiruvahindrapuram B, Liston E, Reuter MS, Manshaei R, Cohn I, Jobling R, Kim RH, Mital S, Ungar WJ. Trio genome sequencing for developmental delay and pediatric heart conditions: A comparative microcost analysis. Genet Med. 2022 Feb 23:S1098-3600(22)00036-3. Epub ahead of print. PMID: 35219592.

  • Pollard S, Weymann D, Chan B, Ehman M, Wordsworth S, Buchanan J, Hanna TP, Ho C, Lim HJ, Lorgelly PK, Raymakers AJN, McCabe C, Regier DA. Defining a Core Data Set for the Economic Evaluation of Precision Oncology. Value Health. 2022 Feb 23:S1098-3015(22)00055-9. Epub ahead of print. PMID: 35216902.

  • Leppig KA, Kulchak Rahm A, Appelbaum P, Aufox S, Bland ST, Buchanan A, Christensen KD, Chung WK, Clayton EW, Crosslin D, Denny J, DeVange S, Gordon A, Green RC, Hakonarson H, Harr MH, Henrikson N, Hoell C, Holm IA, Kullo IJ, Jarvik GP, Lammers PE, Larson EB, Lindor NM, Marasa M, Myers MF, Perez E, Peterson JF, Pratap S, Prows CA, Ralston JD, Rasouly HM, Roden DM, Sharp RR, Singh R, Shaibi G, Smith ME, Sturm A, Thiese HA, Van Driest SL, Williams J, Williams MS, Wynn J, Blout Zawatsky CL, Wiesner GL. The reckoning: The return of genomic results to 1444 participants across the eMERGE3 Network. Genet Med. 2022 Feb 22:S1098-3600(22)00031-4. PMID: 35216901.

  • Cernat A, Bashir NS, Ungar WJ. Considerations for developing regulations for direct-to-consumer genetic testing: a scoping review using the 3-I framework. J Community Genet. 2022 Feb 16. Epub ahead of print. PMID: 35171498.

  • Vu M, Degeling K, Thompson ER, Blombery P, Westerman D, IJzerman MJ. Health economic evidence for the use of molecular biomarker tests in hematological malignancies: a systematic review. Eur J Haematol. 2022 Feb 14. Epub ahead of print. PMID: 35158410.

  • Goranitis I, Wu Y, Lunke S, White SM, Tan TY, Yeung A, Hunter MF, Martyn M, Gaff C, Stark Z. Is faster better? An economic evaluation of rapid and ultra-rapid genomic testing in critically ill infants and children. Genet Med. 2022 Feb 15:S1098-3600(22)00029-6. Epub ahead of print. PMID: 35181209.

  • Hajek C, Hutchinson AM, Galbraith LN, Green RC, Murray MF, Petry N, Preys CL, Zawatsky CLB, Zoltick ES, Christensen KD; Imagenetics METRICS Team. Improved provider preparedness through an 8-part genetics and genomic education program. Genet Med. 2022 Jan;24(1):214-224.  Epub 2021 Nov 30. PMID: 34906462.

  • Ten Ham RMT, Walker SM, Soares MO, Frederix GWJ, Leebeek FWG, Fischer K, Coppens M, Palmer SJ. Modeling Benefits, Costs, and Affordability of a Novel Gene Therapy in Hemophilia A. Hemasphere. 2022 Jan 28;6(2):e679. Erratum in: Hemasphere. 2022 Feb 15;6(3):e698. PMID: 35141470; PMCID: PMC8820916.

  • Zhang J, IJzerman MJ, Oberoi J, Karnchanachari N, Bergin RJ, Franchini F, Druce P, Wang X, Emery JD. Time to diagnosis and treatment of lung cancer: A systematic overview of risk factors, interventions and impact on patient outcomes. Lung Cancer. 2022 Jan 25;166:27-39. Epub ahead of print. PMID: 35152171.

  • de Rouw N, de Boer M, Boosman RJ, van den Heuvel MM, Burger DM, Lieverse JE, Derijks HJ, Frederix GWJ, Ter Heine R. The pharmacoeconomic benefits of pemetrexed dose individualization in lung cancer patients. Clin Pharmacol Ther. 2022 Jan 20. Epub ahead of print. PMID: 35048355.

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